JMF Diagnostic Centers

Experts have estimated that as many as 500,000 cases of PI remain undiagnosed in the United States. Our goal is to give every child a chance to lead a healthy, normal life."

–
Fred Modell, on the opening of the Jeffrey Modell Diagnostic Center for Primary Immunodeficiencies (PI) at Emory Children’s Center in Atlanta, May 14, 2007.

Baxter is pleased to support the Jeffrey Modell Foundation (JMF) in opening Diagnostic Centers throughout the country. These centers can be a resource for you and your family.

JMF Diagnostic Centers
	Cincinnati Children’s Hospital Medical Center dedicated the Jeffrey Modell Foundation (JMF) Diagnostic Center for Primary Immunodeficiencies on October 2, 2009.“We are truly grateful for Baxter’s support that allows us to continue our research into the genetic causes of Primary Immunodeficiency diseases and promotion of the importance of early diagnosis and treatment,”said Arnold Strauss, MD, director of the Cincinnati Children’s Research Foundation and the medical center’s chief medical officer.
	In July 2008, Children’s Memorial Hospital of Chicago celebrated the opening of a Jeffrey Modell Foundation Diagnostic Center for Primary Immunodeficiencies supported by Baxter Healthcare Corporation. The diagnostic center aims to focus on the diagnosis, care, and treatment of children suffering with Primary Immunodeficiency Disorders (PID).
	The Jeffrey Modell Diagnostic Center for Primary Immunodeficiencies at the University of California – San Francisco (UCSF) opened in May 2007 with support from Baxter Healthcare Corporation. “The educational and diagnostic programs made possible through the Jeffrey Modell Diagnostic Center provide a framework within which we can reach out to the community as a center of excellence,”says Jennifer Puck, MD, Professor of Pediatrics and Human Genetics and Director of the center at UCSF."
	Baxter Healthcare Corporation and the Jeffrey Modell Foundation (JMF) provided funding for a state-of-the-art molecular diagnostic laboratory at the Center for Immunology Research, Seattle Children’s Hospital. Hans Ochs, M.D., Professor of Pediatrics and the Jeffrey Modell Chair of Pediatric Immunology Research, says the center provides“cutting edge research and diagnostic opportunities not only for Seattle, but to colleagues in the U.S. and around the world.”
	The Jeffrey Modell Diagnostic Center for Primary Immunodeficiencies at Children’s Hospital of Wisconsin opened in January 2007. Supported by a grant from Baxter, this center offers clinical programs and innovative research for patients throughout the Midwest.
	The Jeffrey Modell Diagnostic Center for Primary Immunodeficiencies at Louisiana State University Health Sciences Center opened in December 2006, with support from Baxter Healthcare Corporation. Educational and diagnostic programs are available here for patients in New Orleans, the mid-southern states, Latin America and the Caribbean.
	The Jeffrey Modell Diagnostic Center for Primary Immunodeficiencies at Emory Children’s Center in Atlanta was dedicated in December, 2005. Supported by a grant from Baxter Healthcare Corporation, the facility serves as a Center of Excellence in Immunology for patients in the southeastern states, providing diagnostic and treatment services for PI.

GAMMAGARD LIQUID [Immune Globulin Infusion (Human)] 10%

Indications

GAMMAGARD LIQUID is used to treat patients with primary immunodeficiency diseases (PI). There are many forms of PI. The most common types of PI result in an inability to make a very important type of protein called antibodies, which help the body fight off infections from bacteria or viruses. GAMMAGARD LIQUID is made from human plasma that is donated by healthy people. GAMMAGARD LIQUID contains antibodies collected from these healthy people that replace the missing antibodies in PI patients.

Detailed Important Risk Information for Patients

Tell your healthcare provider about any side effect that bothers you or that does not go away.

GAMMAGARD LIQUID can cause the following serious reactions:

Severe allergic reactions causing difficulty in breathing or skin rashes
Decreased kidney function or kidney failure
Blood clots in the heart, brain, lungs or elsewhere in the body
Severe headache, drowsiness, fever, painful eye movements, or nausea and vomiting
Dark colored urine, swelling, fatigue, or difficulty breathing

Tell your healthcare provider if you have a history of poor kidney function or kidney failure. If so, GAMMAGARD LIQUID should be administered at the slowest intravenous infusion rate as determined by your healthcare provider.

Contact your healthcare provider or call emergency services immediately if you have reduced urination, sudden weight gain, or swelling in your legs. These could be signs of a kidney problem.

Do not use GAMMAGARD LIQUID if you have a known history of a severe allergic reaction to immune globulin or other blood products. If you have such a history, discuss this with your healthcare provider to determine if GAMMAGARD LIQUID can be given to you. Tell your healthcare provider if you have a condition called selective (or severe) immunoglobulin A (IgA) deficiency.

If any of the following problems occur after starting treatment with GAMMAGARD LIQUID, stop the infusion immediately and contact your healthcare provider or call emergency services. These could be signs of a serious problem.

Hives, swelling in the mouth or throat, itching, trouble breathing, wheezing, fainting or dizziness. These could be signs of a serious allergic reaction.
Bad headache with nausea, vomiting, stiff neck, fever, and sensitivity to light. These could be signs of irritation of the lining around your brain.
Reduced urination, sudden weight gain, or swelling in your legs. These could be signs of a kidney problem.
Pain, swelling, warmth, redness, or a lump in your legs or arms. These could be signs of a blood clot.
Brown or red urine, fast heart rate, yellow skin or eyes. These could be signs of a liver problem or a blood problem.
Chest pain or trouble breathing, blue lips or extremities. These could be signs of a serious heart or lung problem.
Fever over 100°F. This could be a sign of an infection.

These are not all of the possible side effects with GAMMAGARD LIQUID. You can ask your healthcare provider for physician’s information leaflet.

GAMMAGARD LIQUID is made from human plasma. It may carry a risk of transmitting viruses.

The following one or more possible reactions may occur at the site of infusion. These generally go away within a few hours, and are less likely after the first few infusions.

Mild or moderate pain
Swelling
Itching

Redness
Bruising
Warmth

During the infusion of GAMMAGARD LIQUID, look out for the first signs of the following common side effects:

Headache
Migraine
Fever
Fatigue
Itching
Rash/Hives
Cough

Chills/Shaking chills
Dizziness
Nausea/Vomiting
Faster Heart Rate
Upper Abdominal Pain
Increased Blood Pressure

Whenever giving yourself treatments at home, you should have another responsible person present to help treat side effects or get help should a serious adverse reaction occur. Ask your healthcare provider whether you should have rescue medications, such as antihistamines or epinephrine.

Please see the Full Prescribing Information for GAMMAGARD LIQUID [Immune Globulin Infusion (Human)] 10% for full prescribing details.