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Immunoglobulin (IgG) therapy temporarily replaces infection-fighting antibodies that some people with primary immune deficiency (PI) diseases are missing. So it’s beneficial for a number of types of PI, including but not limited to:1

  • X-linked Agammaglobulinemia (XLA)
  • Common Variable Immunodeficiency (CVID)
  • Severe Combined Immunodeficiency (SCID)
  • Wiskott Aldrich Syndrome
  • Congenital Agammaglobulinemia

IVIG and SubQ

You can receive IgG infusions in two ways:

  • Intravenously (IVIG), which means into a vein
  • Subcutaneously (SubQ), which means under the skin

You and your doctor will decide what’s best for your health needs, abiltiy and lifestyle. Here are some quick facts:

How infused? IVIG:
Directly into the bloodstream through a vein.1

SubQ:
Subcutaneously into the fatty tissue under your skin.1
How delivered? IVIG:
Through an IV using an IV pump.1

SubQ:
Through a small portable pump.1
How often? IVIG:
every 3-4 weeks1

SubQ:
Weekly2
Who administers? IVIG:
By a nursing professional.

SubQ:
Self-infused at home or administered by a family caregiver after initial training.3
Where infused? IVIG:
Outpatient clinic, infusion center or your home.1

SubQ:
At home or while traveling on business or vacation.3
Lifestyle factors IVIG:
Ideal for individuals who prefer professional care and appreciate the social interaction with other patients and their families.

SubQ:
More flexibility and responsibility. Ideal for people who travel.3
More information IVIG:
Learn about IVIG

SubQ:
Learn about SubQ

Other Treatments for PI

For those types of primary immune deficiency disease which don't benefit from IgG infusions, such as Chronic Granulomatous Disease and Complement Deficiencies, there are other treatments available, including antibiotics, stem cell transplants, granulocyte-colony stimulating factor (G-CSF), gamma interferon, and PEG-ADA.1 Your doctor will help you decide which treatment is best for you.

  1. Blaese RM, Winkelstein J. Patient & Family Handbook for Primary Immunodeficiency Diseases. Towson, MD: Immune Deficiency Foundation; 2007: .93-94.
  2. GAMMAGARD LIQUID [Immune Globulin Infusion (Human)] 10% [package insert]. Westlake Village, CA. Baxter International Inc.; July 2011.
  3. Berger, M. Clinical Focus on Primary Immune Deficiencies, Subcutaneous IgG Therapy in Immune Deficiency Diseases Towson, MD: Immune Deficiency Foundation, 2007.