Intended for U.S.When people with PI first start SubQ treatment, they may have reactions at the location where they infuse the IgG.1 This is commonly called “local site reactions.”
Local Site Reactions
Below are local site reactions that have been observed in studies of subcutaneous IgG therapy:
- Pain
- Redness
- Swelling
- Bruising
- Itching
- Warmth
General Side Effects
General side effects have also been reported in studies of subcutaneous IgG therapy:
- Headache
- Chills/Shaking chills
- Migraine
- Dizziness
- Fever
- Nausea/Vomiting
- Fatigue
- Faster Heart Rate
- Itching
- Upper Abdominal Pain
- Rash/Hives
- Increased Blood Pressure
- Cough
The following reactions have been reported to occur with intravenous immune globulin treatment, and may occur with subcutaneous immune globulin treatment:
- Hives, swelling in the mouth or throat, itching, trouble breathing, wheezing, fainting or dizziness. These could be signs of a serious allergic reaction.
- Bad headache with nausea, vomiting, stiff neck, fever, and sensitivity to light. These could be signs of irritation of the lining around your brain.
- Reduced urination, sudden weight gain, or swelling in your legs. These could be signs of a kidney problem.
- Pain, swelling, warmth, redness, or a lump in your legs or arms. These could be signs of a blood clot.
- Brown or red urine, fast heart rate, yellow skin or eyes. These could be signs of a liver problem or a blood problem.
- Chest pain or trouble breathing, blue lips or extremities. These could be signs of a serious heart or lung problem.
- Fever over 100°F. This could be a sign of an infection.
Ask your healthcare provider for more information on possible side effects associated with immunoglobulin replacement therapy. Remember to talk to your healthcare provider about side effects.
If you would like to report an adverse reaction, contact Baxter Global Pharmacovigilance: 866-888-2472 or global_pharmacovigilance_deerfield@baxter.com.
If you have a medical/clinical question regarding the use of Baxter IgG products, contact Baxter Medical Information: 866-424-6724 or medinfo@baxter.com
Learn about Baxter IgG therapies.
- GAMMAGARD LIQUID [Immune Globulin Infusion (Human)] 10% [package insert]. Westlake Village, CA: Baxter Healthcare Corporation; July 2011.
- Berger, M. Clinical Focus on Primary Immune Deficiencies. Issue 13. Towson, MD: Immune Deficiency Foundation; Feb 2008.
- Blaese RM, ed. IDF Guide for Nurses on Immune Globulin Therapy for Primary Immunodeficiency Diseases. 2nd ed. Towson, MD: Immune Deficiency Foundation; 2007.
