FAQs on PI

Read Frequently Asked Questions on primary immunodeficiency (PI).

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Nurse Partner

Talk to an experienced healthcare professional about your IgG administration questions.

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IVIG Side Effects

The majority of intravenous immunoglobulin (IVIG) side effects are mild, transient, and self-limited and do not require discontinuation of therapy. Some common side effects are1:

  • Headache
  • Chills/Shaking chills
  • Migraine
  • Dizziness
  • Fever
  • Nausea/Vomiting
  • Fatigue
  • Faster Heart Rate
  • Itching
  • Upper Abdominal Pain
  • Rash/Hives
  • Increased Blood Pressure
  • Cough

Serious adverse events have been reported to occur in association with IVIG,2,3 such as:

  • Hives, swelling in the mouth or throat, itching, trouble breathing, wheezing, fainting or dizziness. These could be signs of a serious allergic reaction.
  • Bad headache with nausea, vomiting, stiff neck, fever, and sensitivity to light. These could be signs of irritation of the lining around your brain.
  • Reduced urination, sudden weight gain, or swelling in your legs. These could be signs of a kidney problem.
  • Pain, swelling, warmth, redness, or a lump in your legs or arms. These could be signs of a blood clot.
  • Brown or red urine, fast heart rate, yellow skin or eyes. These could be signs of a liver problem or a blood problem.
  • Chest pain or trouble breathing, blue lips or extremities. These could be signs of a serious heart or lung problem.
  • Fever over 100°F. This could be a sign of an infection.

Your doctor can help you determine whether you might be at risk of developing such adverse events. Please talk to your doctor if you have any concerns. Please review your product insert for full details on all warnings, precautions and adverse events.

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Find out about Baxter IgG Therapies

If you would like to report an adverse reaction, contact Baxter Global Pharmacovigilance: 866-888-2472 or global_pharmacovigilance_deerfield@baxter.com.

  1. Bertorini TE, Nance AM, Horner LH, Greene W, Gelfand MS, Jaster JH. Complications of intravenous gammaglobulin in neuromuscular and other diseases. Muscle & Nerve 1996;19: 388-391.
  2. Ballow M. Safety of IGIV therapy and infusion-related adverse events. Immunol Res 2007; 38:122-132.
  3. Ippoliti C, Williams LA, Huber S. Toxicity of rapidly infused concentrated intravenous immune globulin. Clinical Pharmacology 1992;11:1022-1026.